Apoptosis Induction by the 5􀀁 NCR of Infectious Bursal Disease Virus

Apoptosis Induction by the 5 NCR of Infectious Bursal Disease Virus

Virus invasion and replication can induce apoptosis and play an important role in the life cycle of viruses. To illustrate the relationship between apoptosis induction and the non-coding region (NCR) of infectious bursal disease virus (IBDV), the 5 NCR of Harbin-1 (a very virulent IBDV) segment A was sequentially deleted using PCR and exchanged with the corresponding region of the mild virulent...

Characterization of a Highly Virulent Infectious Bursal Disease Virus

Conformational analysis of Infectious bursal disease virus

Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone conformation. Materials and Methods: IBDV VP5 protein segment designated as RATH peptide were synthesized using solid phase peptide synthesis and their s...

Structure of infectious bursal disease virus.

Infectious bursal disease virus of chickens was purified, and its structure was examined by the negative-staining technique in the electron microscope. The buoyant density of infectious bursal disease virus in CsCl was found to be 1.34 g/cm(3). The morphological details suggest that the capsid of the virion consists of a single layer of 32 capsomeres arranged in 5:3:2 symmetry. The virion measu...

Intracellular interference of infectious bursal disease virus.

A search for dominant-negative mutant polypeptides hampering infectious bursal disease virus (IBDV) replication has been undertaken. We have found that expression of a mutant version of the VP3 structural polypeptide known as VP3/M3, partially lacking the domain responsible for the interaction with the virus-encoded RNA polymerase, efficiently interferes with the IBDV replication cycle. Transfo...